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Pro Research: Wall Street dives into Neurocrine Biosciences

2023.12.17 10:27


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In a competitive and ever-evolving biopharmaceutical landscape, Neurocrine (NASDAQ:) Biosciences, Inc. (NASDAQ: NBIX) stands out with its focus on neurological and endocrine-related diseases and disorders. Analysts have been closely monitoring the company’s performance and pipeline developments, providing insights that are crucial for investors looking to understand the potential risks and rewards associated with NBIX.

Performance in Different Markets

The core product of Neurocrine Biosciences, Ingrezza, used to treat Tardive Dyskinesia, continues to perform robustly, though concerns have been raised about its long-term potential not meeting Street expectations despite short-term durability. The company’s focus on diversifying its revenue base is marked by R&D efforts, with multiple Phase 2 readouts expected in 2024 and several Phase 1 initiations planned for its muscarinic portfolio.

Product Segments and Pipeline

Neurocrine’s pipeline is a mix of promise and setbacks. The company’s “20 in 5” goal is to produce 20 developmental candidates in the next five years, which should also enhance their ability to assess external business development opportunities. The recent success of crinecerfont in phase III trials for congenital adrenal hyperplasia (CAH) has been a silver lining, potentially setting the stage for a new blockbuster product. Neurocrine anticipates significant catalysts in 2024 that could de-risk its historically risky pipeline, including five Phase 2 top-line reports. A strong patient advocacy network for CAH suggests a potentially robust launch for crinecerfont due to the lack of available therapies.

Competitive Landscape and Market Trends

Neurocrine operates in a highly competitive market, where innovation and timely product development are key. The variety in the pipeline positions Neurocrine competitively in the neurology space, with new treatments and strategic acquisitions speculated to bolster its pipeline. Analysts also view the company as a potential acquisition target itself, given its strong product Ingrezza and promising pipeline candidates.

Regulatory Environment and Customer Base

The regulatory environment remains a critical factor for Neurocrine. The company has received Breakthrough Status for CAH, which is a significant milestone that could expedite its drug development process. Analysts anticipate that the company will navigate through these milestones effectively, which could lead to significant value appreciation.

Management and Strategy

Under new leadership, Neurocrine has been refocusing on validated biology and lower-risk innovation. The strategic pivot is expected to leverage the company’s core strengths and improve its risk profile, as reflected by the maintained “Overweight” rating by analysts.

External Factors

The Inflation Reduction Act (IRA) continues to be a point of concern for analysts, with potential impacts on long-term Ingrezza prospects due to changes in drug pricing and reimbursement. Moreover, penetrating the Long-Term Care (LTC) market is associated with high costs.

Upcoming Product Launches

Crinecerfont’s upcoming launch, following a likely approval towards the end of 2024, is highly anticipated. The drug’s potential for treating CAH could position it as a standard treatment with a significant market share.

Stock Performance

Neurocrine’s stock has seen fluctuations in response to pipeline developments and market conditions. Analysts have provided varied price targets, reflecting their individual assessments of the company’s risk-reward scenario and future prospects.

Bear Case

Is Neurocrine Biosciences facing significant pipeline risks?

Despite the breadth of assets targeting muscarinic mechanisms and the potential for success, Neurocrine has experienced pipeline setbacks, most notably with the failure of ‘352 for epilepsy and ‘864 for anhedonia. These failures limit the company’s ability to diversify beyond Ingrezza, raising concerns about its long-term growth potential. Analysts have adjusted their price targets accordingly, reflecting increased risk perceptions and the need for strategic decisions to rebuild the pipeline.

Will Neurocrine’s reliance on Ingrezza affect its growth prospects?

While Ingrezza’s strong sales continue, there is skepticism about the drug’s ability to sustain long-term growth, particularly with the potential impact of the IRA. The company’s reliance on this single product could pose risks to its valuation if pipeline developments do not yield successful new treatments.

Bull Case

Can Neurocrine Biosciences capitalize on its recent clinical successes?

The success of crinecerfont in phase III trials for CAH has been a significant boost for Neurocrine. Analysts believe that this drug has the potential to become a standard treatment for CAH, with a high probability of regulatory approval. The company’s strategic acquisitions and focus on low-risk innovation could further enhance its growth trajectory.

Is the market underestimating Neurocrine’s potential catalysts?

Upcoming catalysts, including phase II readouts for ‘352 in focal onset seizures and the muscarinic program, could provide significant upside for Neurocrine. Analysts remain optimistic about the company’s ability to deliver on these fronts, which could lead to a revaluation of NBIX shares.

SWOT Analysis

Strengths:

– Strong sales performance of Ingrezza.

– Positive phase III trial results for crinecerfont in CAH.

– Strategic focus on low-risk innovation and validated biology.

Weaknesses:

– Pipeline setbacks with the failure of two mid-stage programs.

– Heavy reliance on Ingrezza for revenue.

– Potential impact of IRA on long-term prospects.

Opportunities:

– Market expansion through strategic acquisitions.

– Upcoming product launches and pipeline readouts.

– Untapped market potential for Tardive Dyskinesia treatment.

Threats:

– Competitive market with rapid innovation.

– Regulatory hurdles and insurance coverage issues.

– Execution risks in commercializing new products.

Analyst Targets

– Barclays Capital Inc.: Overweight rating with a price target of $125.00 (December 7, 2023).

– BMO Capital Markets Corp.: Market Perform rating with a price target of $100.00 (December 6, 2023).

– RBC Capital Markets: Sector Perform rating with a price target of $128.00 (November 1, 2023).

– Piper Sandler: Neutral rating with a price target of $100.00 (November 1, 2023).

The analysis timeframe spans from September to December 2023.

InvestingPro Insights

Neurocrine Biosciences, Inc. (NASDAQ: NBIX) has been a focal point for investors, given its promising pipeline and strategic initiatives. To provide a deeper understanding of the company’s financial health and market performance, here are key insights derived from InvestingPro:

The company’s market capitalization stands at a robust $11.81 billion, reflecting a significant presence in the biopharmaceutical sector. Neurocrine’s P/E ratio, a measure of its current share price relative to its per-share earnings, is 61.11, which adjusts to a more favorable 38.56 when considering the last twelve months as of Q3 2023. This adjustment suggests a better valuation of the company when recent earnings are taken into account. Additionally, the PEG ratio for the same period is 0.29, indicating potential undervaluation relative to its earnings growth.

InvestingPro Tips highlight that Neurocrine Biosciences has high earnings quality, with free cash flow exceeding net income, and yields a high return on invested capital. These factors are crucial for investors assessing the company’s efficiency and profitability. Moreover, the company’s net income is expected to grow this year, providing a positive outlook for future financial performance.

For investors seeking more in-depth analysis, InvestingPro offers additional tips on Neurocrine Biosciences, including insights on earnings revisions, valuation multiples, and stock volatility. Subscribers can access these tips at It’s worth noting that the InvestingPro subscription is now on a special Cyber Monday sale, offering up to 60% off. To further enhance the value, users can use the coupon code research23 to get an additional 10% off a 2-year InvestingPro+ subscription.

With 18 additional InvestingPro Tips listed, subscribers can delve into a comprehensive analysis that could be instrumental in making informed investment decisions. These tips cover various aspects of the company’s financial health and market performance, ensuring that investors have a well-rounded view of Neurocrine Biosciences.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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